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This is evidenced by the significant deficiency of its active form, calcitriol, in affected women ( Vitamin D influences steroidogenesis by upregulating aromatase gene expression, thereby enhancing the conversion of androgens to estrogens (estradiol and estrone) and stimulating progesterone production ( The therapeutic potential of vitamin D in PCOS is largely attributed to its systemic antioxidant and anti-inflammatory properties ( i.e

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10.1161/CIRCULATIONAHA.122.061033 73 ScillettaS.Di MarcoM.MianoN.FilippelloA.Di MauroS.ScamporrinoA.et al (2023)

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The better reproducibility of the conversion SIDA method might be attributed to the higher concentrations of CNCbl being analyzed after pre-concentration, while much lower levels of native CNCbl present in the samples were determined by the native SIDA method

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